Independent biomechanical evidence

Validated
Biomechanics.

We generate independent biomechanical evidence, validated across all four domains, from in-silico models to in-vivo results. The proof regulators, clinicians, and device makers trust across a device's lifecycle.

On-axis RoM · cadaveric vs FEA · 7.5 N·m
0 0.4 0.8 1.2 range of motion (°) NC AR LB NC AR LB Male Female agreement ≤ 0.05°
One of many validated results: sacroiliac-joint range of motion.
20+
510(k) clearances supported by our biomechanical evidence.
250+
Peer-reviewed publications, presentations, lectures, and seminars.
30+
Device-manufacturer partnerships across the field.
2
Acquisitions informed by our due-diligence evidence.
100+
Co-author collaborations.
ISO 17025
The international standard our testing is held to.
What we do

Biomechanical evidence, generated and validated.

We produce biomechanical data across the musculoskeletal system and every specialty our published work reaches. Every result across the four domains is validated and produced in accordance with ISO/IEC 17025.

Four domains, cross-validated

Sequence ·  — — —  Cross-validation

Ground truth In silico Computational In vitro Composite In situ Cadaveric In vivo Clinical Ground truth In silico Computational In vitro Composite In situ Cadaveric In vivo Clinical
Finite element analysis of a femur showing von Mises stress distribution
In silico · Computational

Validate once. Iterate forever.

We build computational models, digital twins of physical models, and validate them against physical ground truth: in-vitro, in-situ, or in-vivo, depending on the experiment. Many are already validated and ready to run, and we build custom validated models to order. Once a model is validated, testing the next design, technique, or anatomy is computation, not another study. Send us a device and imaging, and we return results.

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Instron mechanical testing frame
In vitro · Composite

Repeatable, at any volume.

Standardized non-cadaveric testing on synthetic bone, metal, and other analogs gives high-volume, repeatable mechanical evaluation, plus usability and surgical-training labs. It's validated against in-situ and in-vivo evidence, so synthetic results map to real tissue and real patients.

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Anatomical plate of radius and ulna
In situ · Cadaveric

Ground truth, in tissue.

Human cadaveric biomechanics is the highest-fidelity physical model, and where surgical-technique and usability work happens in real tissue. It's validated against in-vivo evidence and grounds it in turn: cadaveric and clinical results check one another.

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Shoulder X-ray image
In vivo · Clinical

Proof, in living patients.

Biomechanical validation in living patients is the ultimate ground truth. It spans motion and kinematics, load and stress transfer, fixation and migration, fusion, alignment, and the full range of how a device behaves in the body, measured from clinical imaging and follow-up. In-vivo evidence is what the other three domains are ultimately checked against.

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In person, in our lab

Hands-on, same rigor, in our surgical lab.

A fully-equipped surgical wet lab, 30 minutes from DFW, for device training, usability evaluation, and cadaveric technique work — tissue, imaging, multiple stations, faculty, and live streaming, under one roof.

Five AATB-accredited tissue banks · 60+ physicians nationwide · Live streaming · 30 minutes from DFW
Independent by structure

Evidence that answers only to the data.

That's why regulatory bodies, peer reviewers, clinicians, device manufacturers, and investors all rely on our findings. Everyone across a device's lifecycle needs the biomechanics to hold up. And it's why your design stays entirely yours: no outside institution shapes a result, claims your IP, or stands between you and the work.

Across the lifecycle

Evidence for every decision.

The same evidence supports decisions from first design through post-market. One source, across the device lifecycle.

01Research & Development
02Regulatory clearance
03Marketing claims
04Litigation defense
05Clinical trials
06Post-market evidence
Our work, in the record

Peer-reviewed, and presented widely.

Spine, joint reconstruction, sports medicine, and trauma: independent biomechanical evidence across orthopedic specialties, from cadaveric and computational studies through clinical results. Peer-reviewed, and presented at the field's major meetings.

2026
Sacroiliac Joint Fixation With a Posterior Intra-Articular Implant Versus a Posterolateral Transiliac Implant: A Biomechanical Comparison
N Am Spine Soc J · 26:100871
2025
Biomechanical Restoration in Unilateral Facet Arthroplasty: A Cadaveric Evaluation
N Am Spine Soc J · 23:100766
2025
Fixation of the Sacroiliac Joint: A Cadaver-Based Concurrent-Controlled Biomechanical Comparison of Posterior Interposition and Posterolateral Transosseous Techniques
Neurospine · 22(1):185-193
2024
The Effect of Body Weight on Interfragmentary Fracture Strain in Plate Fixation of Distal Femur Fractures: A Finite Element Analysis
Orthop Traumatol Surg Res · 110(6):103868
2024
Femoral Interference Screw Divergence as a Result of Anteromedial Portal Insertion and Outside-In FlipCutter Femoral Tunnel Drilling: A Cadaveric Study
J Orthop · 52:138-142
2023
Spinolaminar Locking Plates Improve Fixation Strength Compared to Pedicle Screws: A Biomechanical Analysis
Spine Deform · 11(6):1335-1345
2022
Pelvic Stability During Simulated Total Hip Arthroplasty Motions: Comparing Different Hip Positioners
J Orthop · 34:398-403
The team

The engineers behind the work.

A team of engineers and scientists generating independent biomechanical evidence, led by its founders, Jeremi Leasure and Richard Raji, whose backgrounds span computational and physical biomechanics.

Portrait of Jeremi M. Leasure, Co-Founder and CEO of MDevDev Co-Founder & Chief Executive Officer

Jeremi M. Leasure

A licensed professional engineer, Jeremi holds a master's in mechanical engineering from Drexel University and a bachelor's in mechanical engineering from Temple University, with research fellowships in orthopaedic biomechanics at the University of Tübingen and in clinical orthopaedics through the San Francisco Orthopaedic Residency Program. He has led engineering at Aurora Spine, Benvenue Medical, and Stress Engineering Services.

Portrait of Richard O. Raji, Co-Founder and CTO of MDevDev Co-Founder & Chief Technology Officer

Richard O. Raji

A licensed professional engineer, Richard holds a master's in bioengineering from UC Berkeley and a bachelor's in mechanical engineering from Afe Babalola University, with doctoral work in translational health sciences at George Washington University. He has directed orthopedic research programs at UCSF Health (Stanyan Hospital) and Dignity Health (St. Mary's), and led stability-subsystem simulation for UC Berkeley's Hyperloop team.

Recognition
Spine Section & Research Award nominationsAAOS · 2024
Spine Section & Research Award nominationsORS · 2023, 2024
Best New Technology in SpineOrthopedics This Week / NASS · 2022
Business Innovation Award, FinalistORS · 2018, 2019
P30 Young Investigator Slam, FinalistUCSF Orthopedics · 2019
Research AwardCalifornia Orthopaedic Association · 2015
Whitecloud AwardScoliosis Research Society · 2014
Healthcare Value Award, NomineeNASS · 2014
Innovation AwardMaterialise World Summit · 2013
From the lab

In the field, and in the record.

Read the newsroom
510(k) clearanceWenzel · 2025
panaSIa, first expandable posterior SI-fusion device
Cleared on our cadaveric and computational biomechanical evidence.
510(k) clearanceSpinal Simplicity · 2025
Patriot SI, guided posterior SI implant
Cleared on our standalone biomechanical evidence.
PublicationNeurospine · 2025
Titanium interbody cages under impaction
An in-vitro model of mass and surface-topography loss in 3D-printed spinal cages.
510(k) clearanceNevro · 2024
Nevro V1, integrated sacroiliac fixation
Cleared on our standalone evidence, part of Nevro's acquisition of Vyrsa.
PublicationJ Am Acad Orthop Surg · 2024
Thermal damage in orthopaedics
A review of heat generation and bone injury across orthopedic procedures.
PublicationJ Orthop · 2024
Follow-up and outcomes after hip-fracture surgery
How a missed first post-operative visit drives 90-day complications and readmission.
PublicationSpine · 2023
A decade of lumbar interbody-cage failures
A study of device failures reported to the FDA MAUDE database.
PublicationJ Pain Res · 2023
Interspinous fusion device, REFINE study
Six-month functional outcomes in low-back-pain patients.
PresentationEur Orthop Research Soc · 2023
Acetabular fracture contact mechanics
A biomechanical analysis of fracture displacement and joint contact pressure.

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